In a clinical trial, more patients who responded and continued on CIMZIA versus placebo showed noticeable
improvement in signs and symptoms of moderate to severe Crohn's disease at 26 weeks. Nearly half of those
patients who continued to take CIMZIA were in remission at 26 weeks.
If your doctor has recently prescribed CIMZIA, you may have questions. Get the
information and support you need for a smooth transition into treatment with CIMZIA:
What is the most important information I should know
CIMZIA is a medicine that affects your immune system. CIMZIA can lower the ability of the immune system to fight infections. Serious infections have happened in patients taking CIMZIA. These infections include tuberculosis (TB) and infections caused by viruses, fungi or bacteria that have spread throughout the body. Some patients have died from these infections.
- Your doctor should test you for
TB before starting CIMZIA.
- Your doctor should monitor you
closely for signs and symptoms of TB during treatment with CIMZIA.
You should not start receiving CIMZIA if you have any kind of infection unless your healthcare provider says it is okay.
Before starting CIMZIA, tell your doctor if you:
Think you have an infection, flu-like symptoms, or have any other symptoms of an infection such as:
- fever, sweat, or chills
- muscle aches
- shortness of breath
- blood in phlegm
- weight loss
- warm, red, or painful skin or sores on your body
- diarrhea or stomach pain
- burning when you urinate or urinate more often than normal
- feeling very tired
- Are being treated for an infection.
- Get a lot of infections or have infections that keep coming back.
- Have diabetes, HIV, or a weak immune system. People with these conditions have a higher chance for infections.
- Have tuberculosis (TB), or have been in close contact with someone with TB.
- Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your healthcare provider if you are not sure.
- Live or have lived in certain parts of the country (such as the Ohio and Mississippi River valleys) where there is an increased risk for getting certain kinds of fungal infections (histoplasmosis, coccidioidomycosis, blastomycosis). These infections may develop or become more severe if you take CIMZIA. If you do not know if you have lived in an area where histoplasmosis, coccidioidomycosis, or blastomycosis is common, ask your healthcare provider.
- Have or have had hepatitis B.
- Use the medicine Kineret® (anakinra), Orencia® (abatacept), Rituxan® (rituximab), or Tysabri® (natalizumab).
After starting CIMZIA
If you get an infection, any sign of an infection including a fever, cough, flu-like
symptoms, or have open cuts or sores on your body, call your doctor right away.
CIMZIA can make you more likely to get infections or make any infection that you
may have worse.
Certain types of cancer
- There have been cases of unusual cancers in children and teenage patients using TNF-blocking agents.
- For people taking TNF-blocker medicines, including CIMZIA, the chances of getting lymphoma or other cancers may increase.
- People with RA, especially more serious RA, may have a higher chance for getting a kind of cancer called lymphoma.
What is CIMZIA?
CIMZIA is a prescription medicine called a Tumor Necrosis Factor (TNF) blocker.
CIMZIA is used in adult patients to:
- Lessen the signs and symptoms of moderately to severely active Crohn’s disease (CD) in patients who have not been helped enough by usual treatments
- Treat moderately to severely active rheumatoid arthritis (RA)
- Treat active psoriatic arthritis (PsA)
- Treat active ankylosing spondylitis (AS)
What should I tell my doctor before starting treatment with CIMZIA?
CIMZIA may not be right for you. Before starting CIMZIA, tell your doctor about
all of your medical conditions, including if you:
- Have an infection. (See, 'What
is the most important information I should know about CIMZIA?")
- Have or have had any type of cancer.
- Have congestive heart failure.
- Have seizures, any numbness or
tingling, or a disease that affects your nervous system such as multiple sclerosis.
- Are scheduled to receive a vaccine.
Do not receive a live vaccine while taking CIMZIA.
- Are allergic to any of the ingredients
in CIMZIA. See the end of this Medication Guide for a list of the ingredients in CIMZIA.
- Are pregnant or planning to become pregnant. It is not known if CIMZIA will harm your unborn baby. Tell your healthcare provider right away if you become pregnant while receiving CIMZIA.
Pregnancy Registry: If you become pregnant while taking CIMZIA, talk to your healthcare provider about registering in the pregnancy exposure registry for CIMZIA. You can enroll in this registry by calling 1-877-311-8972. The purpose of this registry is to collect information about the safety of CIMZIA during pregnancy.
- Are breastfeeding or plan to breastfeed. It is not known if CIMZIA passes into your breast milk. You and your healthcare provider should decide if you will receive CIMZIA or breastfeed.
Tell your healthcare provider about all the medicines you take,
including prescription and over-the-counter medicines, vitamins and herbal supplements. Especially tell your healthcare provider if you take the following medicines due to a higher chance for serious infections:
You should not take CIMZIA while you take one of these medicines.
(anakinra), Orencia® (abatacept),
Rituxan® (rituximab) or Tysabri® (natalizumab).
- Medicines called Tumor Necrosis Factor (TNF) blockers such as Remicade® (infliximab), Humira®
(adalimumab), Enbrel® (etanercept),
Serious infections have happened in patients taking CIMZIA, including tuberculosis
(TB) and infections caused by viruses, fungi, or bacteria that have spread throughout
the body. Some patients have died from these infections. Please read
the CIMZIA Important Safety Information
for additional information on CIMZIA and discuss it with your doctor.
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