CIMZIA is used to lessen the signs and symptoms of moderately to severely active
Crohn's disease in adults who have not been helped enough by usual treatments.
In people with Crohn's disease, the immune system produces too much of a protein
called tumor necrosis factor-alpha (TNF-alpha). TNF-alpha triggers inflammation,
which can lead to inconvenient and often painful symptoms, some of which can cause
damage to your gastrointestinal tract.
CIMZIA is a PEGylated TNF blocker
CIMZIA blocks the action of TNF, a substance produced by cells of the immune system to induce inflammation. CIMZIA is the first and only PEGylated biologic treatment for Crohn's disease. PEGylation has been shown to help the medicine stay in the body.
What clinical studies with CIMZIA have shown
In a clinical trial, more patients who responded and continued on CIMZIA versus placebo showed noticeable improvement in signs and symptoms of moderate to severe Crohn's disease at 26 weeks.
In a different clinical trial, more patients on CIMZIA showed significant improvement in signs and symptoms at 6 weeks and 26 weeks versus placebo.
These studies involved adults with moderately to severely active Crohn's disease and were evaluated based on the Crohn's Disease Activity Index (CDAI), a measurement many researchers use to determine the level of Crohn's disease activity. The patients participating in the study had CDAI scores ranging from 220 to 450, with a higher score indicating greater disease activity. (If you have questions about the CDAI or about how to use it to track disease improvement, ask your doctor.)
Patients 65 years of age or older, patients with other long term medical conditions,
or taking certain other drugs that affect the immune system, such as corticosteroids
or methotrexate, may be at a greater risk of infection.
There have been cases of unusual cancers in children and teenage patients using
tumor necrosis factor (TNF) blockers. For people taking TNF blockers, including
CIMZIA, the chances of getting lymphoma may increase. People with rheumatoid arthritis
(RA), especially more serious RA, may have a higher chance for getting a kind of
cancer called lymphoma. CIMZIA is not approved for use in pediatric patients.
Is CIMZIA right for you?
Are you considering a change in treatment for your Crohn's disease, or has your
doctor suggested a change? Perhaps your current treatment is not controlling your
symptoms. Or, maybe your Crohn's is making it difficult for you to do many of the
things you need to do or want to do.
CIMZIA is not a steroid; it is a biologic prescription treatment that is injected. CIMZIA is used to lessen the signs and symptoms of moderately to severely active Crohn's disease in adults who have not been helped enough by usual treatments.
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