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CIMZIA is a biologic rheumatoid arthritis (RA) medication approved for adults with moderately to severely active RA. When RA is active, inflammation is occurring. Inflammation causes joint pain and stiffness but can also cause damage to joints. Joint damage is more likely the longer that RA stays active, so reducing RA activity is key to preventing joint damage that can limit physical activity. CIMZIA reduces RA inflammation—while easing the signs and symptoms of RA.

What clinical studies with CIMZIA have shown

  • CIMZIA LASTS—In clinical studies, at 24 weeks, a majority of patients experienced noticeable improvement in their RA signs and symptoms such as pain, swelling, and tenderness. Patients also experienced improvement in fatigue during the studies. In one of these studies, further joint damage was also prevented when measured at 1 year.
  • CIMZIA provided relief from RA symptoms, helping patients show improvement in doing normal activities, such as showering and putting on clothes, doing chores, walking short distances, and performing simple errands in a clinical study at 1 year.

Important Safety Information

Heart failure, including new heart failure or worsening of heart failure, has been reported in people taking CIMZIA. Symptoms include shortness of breath, swelling of your ankles or feet, or sudden weight gain.

There have been cases of unusual cancers in children and teenage patients using TNF blockers. For people taking TNF blockers, including CIMZIA, the chances of getting lymphoma may increase. People with RA, especially more serious RA, may have a higher chance for getting a kind of cancer called lymphoma. CIMZIA is not approved for use in pediatric patients.

CIMZIA clinical studies: managing rheumatoid arthritis

Is CIMZIA an option for you?

If you and your doctor think the time is right to adjust your treatment plan for moderate to severe RA, ask if CIMZIA may be right for you. CIMZIA may be used with certain other drugs that are used to treat RA and CIMZIA may be used alone. CIMZIA cannot be used with other biologic drugs for RA.

You should not take CIMZIA with Kineret® (anakinra), Orencia® (abatacept), Rituxan® (rituximab), Tysabri® (natalizumab), Remicade® (infliximab), Humira® (adalimumab), Enbrel® (etanercept), or Simponi® (golimumab) due to an increased risk of serious infections.

Use the Doctor Discussion Guide and talk to your doctor about CIMZIA.

Before starting CIMZIA, tell your doctor about all of your medical conditions as well as all the medicines you take. Especially, tell your doctor if you take*: Kineret® (anakinra), Orencia® (abatacept), Rituxan® (rituximab), or Tysabri® (natalizumab). You have a higher chance for serious infections when taking CIMZIA with these medicines. Also tell your doctor if you are taking a tumor necrosis factor (TNF) blocker such as Remicade® (infliximab), Humira® (adalimumab), Enbrel® (etanercept), or Simponi® (golimumab). You should not take CIMZIA while you take one of these medicines. You should also not receive a live vaccine while taking CIMZIA.

*Trademarks of products listed are the property of their respective owners.

You and your doctor will decide which option is best for you. CIMZIA is available by prescription only and is taken by injection (shot) just below the skin. CIMZIA comes in 2 forms. One is a powder that is mixed with sterile water. This form can only be given by a doctor or nurse. The other form is the CIMZIA prefilled syringe.

Prefilled syringe designed for comfort and control in partnership with OXO Good Grips®
  • If you are able to give yourself shots, and your doctor determines that it is appropriate, you may use the CIMZIA prefilled syringe at home or when you travel after you have been trained by a doctor or nurse in proper injection technique. It is also possible for a friend or loved one to be trained to help you with the shot.
  • If you are not able to give yourself shots, your doctor or a nurse can administer CIMZIA in your doctor's office. When CIMZIA is administered by a doctor or nurse, it is given as the powdered form that is mixed with sterile water.
Rheumatoid Arthritis treatment information: Administration

CIMZIA offers flexible dosing

Initial dosing consists of the first 3 doses, which are provided at Week 0, Week 2, and Week 4. Each of the 3 doses is 400 mg, given as 2 separate injections of 200 mg. After the first 3 doses, CIMZIA can be taken as maintenance doses of one 200 mg shot every 2 weeks or two 200 mg shots every 4 weeks. You and your doctor should decide which maintenance dosing is best for you.

What to expect when starting CIMZIA for RA

Important Safety Information

Serious infections have happened in patients taking CIMZIA, including tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections.

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